Positions Available

Scientist in Process Development

Job Summary:

The successful candidate will be expected to characterize antibodies using a variety of techniques including mass spectrometry, peptide mapping (LC-MS, LC-MS/MS), capillary electrophoresis assays, SDS-PAGE, SEC, ion-exchange and other HPLC based assays. In particular, the candidate will be expected to develop peptide maps and perform mass spectrometry analysis for antibody projects. This position will also be responsible for implementing and establishing HPLC based analytical methods and protocols. This candidate will work in a team to provide analytical support for process development projects, upstream and downstream activities. The candidate will be involved in analytical method development and qualification. In addition, this individual will be required to interpret mass spectrometry data and summarize results in a report. The candidate must have excellent written and verbal communication skills.

Education:

PhD in Biochemistry, Chemistry, Biology, Immunology or equivalent.

Requirements:

• PhD plus postdoctoral or 1 or 2 years experience preferably in a biotechnology environment
• Skilled in analytical techniques including Mass Spectrometry, UPLC and HPLC
• Experience with Waters instruments is a plus
• Experience with data management systems and statistical software
• Experience in mass spectrometry and peptide mapping method development and data analysis
• Demonstrated ability to work in a team and fast paced environment
• Excellent written and verbal skills
• Experience with monoclonal antibodies

Informatics Scientist / Sr. Scientist in Translational Medicine

OncoMed Pharmaceuticals is discovering and developing monoclonal antibodies capable of destroying cancer stem cells involved in the formation and growth of solid tumors. We are seeking a biomarker expert to work in the Translational Medicine Group.

The successful candidate will lead and conduct high level data analysis of clinical and preclinical biomarker datasets. They will also contribute significantly to developing the biomarker strategies for OncoMed’s monoclonal antibody therapeutics.

• Responsible for initiating, designing, and managing preclinical and clinical biomarker analysis.
• Identify pharmacodynamic and predictive biomarkers using primary human tumor xenograft data from OncoMed's tumor bank as well as clinical data.
• Derive meaningful biological results from data mining and meta-analysis of large data sets, including genomics, pharmacogenomics, and proteomics, as well as PK/PD analysis.
• Communicate and collaborate with clinical and therapeutic teams to effectively define and report next experimental steps from analyzed data.
• Opportunity to build up the bioinformatics function and play a pivotal role in OncoMed’s drug discovery and development.

• Ph.D. in life sciences, with 4-8 years experience handling of clinical and preclinical biologic data of various kinds including genomic and microarray data.
• Must have comprehensive training in statistics.
• Strong background in biological sciences; experience in oncology and also at the lab bench preferred.
• Experience with analysis of and reporting of clinical datasets.
• Experience with SAS, S/R, Spotfire, Linux/Unix, Matlab, and various pathway analysis tools i.e., Ingenuity, Metacore GeneGo.

Please send CV/Resume to:

Human Resources
OncoMed Pharmaceuticals
800 Chesapeake Drive
Redwood City, CA 94063
hr@oncomed.com