OncoMed Pharmaceuticals, Inc.  
 
 
 

Careers at OncoMed

OncoMed, a pioneer and leader in the development of novel cancer therapies directed toward tumor initiating cells, also known as “cancer stem cells”, fosters a culture of innovation as the company strives to provide significant alternatives for the treatment of cancer.

Headquartered in Redwood City, California, our employees bring a passionate dedication to the advancement of novel treatments for patients with cancer.

Open Positions:


Senior Scientist/Associate Director, Bioassay Development

Job Summary:

OncoMed Pharmaceuticals is developing novel biologic therapies for the treatment of cancer and currently has 7 clinical stage product candidates. Cell-based assays and plate-based binding assays are designed to establish the potency and stability of a drug substance/product. The successful applicant will have primary responsibilities for the design, conduct and oversight of new potency assays, and for enhancing existing methods. In addition, the candidate will be expected to perform routine analysis, as needed, to support process and formulations development. The job is within the Analytical Sciences group, reporting to the Director.

Responsibilities:
  • Lead the development, transfer, qualification and troubleshooting of cell-based bioassays and plate based binding assays
  • Work with members of Quality Control to define and implement strategies for critical reagent preparation and characterization to support cell-based bioassays and ELISA binding assays
  • Establish working relationships with other groups within Research and Development to support the development of the OncoMed pipeline
  • Manage, train and/or mentor others
  • Provide support to upstream, downstream and formulation development groups
Requirements:
  • PhD and 4+ years or MS and 6+ years related pharmaceutical or biotechnology industrial experience with increasing scientific responsibilities in analytical development
  • Proven record of successfully developing and transferring cell-based bioassays
  • Strong technical writing and oral presentation skills
  • Ability to work in a fast-paced team environment and prioritize work from multiple projects within a flexible work schedule
Desired but not required:
  • Knowledge of current regulatory expectations regarding potency assays
  • Knowledge of Notch/Wnt signaling pathways and/or immuno-oncology as it relates to bioassays
  • Experience applying Design of Experiments to assay optimization and qualification

Please click here to submit CV/Resume (email to hr@oncomed.com) indicating the job title you are applying for.



Senior Scientist, Protein Characterization

Job Summary:

OncoMed Pharmaceuticals is developing novel biologic therapies for the treatment of cancer and currently has 7 clinical stage product candidates. This position is for a protein characterization scientist who will help to advance the OncoMed pipeline by defining product Critical Quality Attributes, developing test method for release and stability and supporting process development.
Under limited supervision, the Scientist's primary responsibilities involve the design, conduct and oversight of protein characterization studies. In addition, the candidate will be expected to perform some testing as needed in support of process development. The job is within the Analytical Sciences group, reporting to the Director.

Responsibilities:
  • Define Critical Quality Attributes (CQA) for both early and late phase clinical programs using a combination of chromatographic, electrophoretic and biophysical approaches
  • Perform forced degradation studies to support CQA assessment, process development and specification setting
  • Perform pre-formulation studies
  • Participate in comparability assessments for later stage programs
  • Establish working relationships with other groups within Research and Development to support the development of the OncoMed pipeline
  • Manage, train and/or mentor others
  • Provide support to upstream, downstream and formulation development groups
Requirements:
  • PhD and 4+ years or MS and 6+ years related pharmaceutical or biotechnology industrial experience with increasing scientific responsibilities in analytical development
  • Proven record of successfully developing separation methods for protein therapeutic release, stability, fractionation and/or characterization
  • Strong technical writing and oral presentation skills
  • Ability to work in a fast-paced team environment and prioritize work from multiple projects within a flexible work schedule
Desired but not required:
  • Knowledge of current US and OUS regulatory expectations regarding quality, stability and comparability
  • Experience applying Design of Experiments to assay optimization and qualification

Please click here to submit CV/Resume (email to hr@oncomed.com) indicating the job title you are applying for.



Associate Scientist/Scientist, Cell Line Development

Job Summary:

The cell line development group at OncoMed is looking for a creative, highly motivated individual with expertise in molecular and cell biology. The Associate Scientist/Scientist will be a critical member of the group which focuses on the generation of highly productive CHO cell lines with desired protein quality attributes for the production of oncology biotherapeutics. The candidate effectively plans and executes experiments, and clearly communicates results.

Responsibilities:
  • Perform CHO cell line development to generate manufacturing cell lines secreting novel therapeutic proteins. This work includes transfection, selection, single cell cloning with imaging, cell banking, and evaluation of clonal cell lines for productivity, quality, and stability
  • Utilize imaging equipment for confirming monoclonality and microbioreactors for fed batch evaluations
  • Work with CMO’s to transfer banking and inoculum expansion processes
  • Stay up to date on published literature and develop innovative cell line development technologies
  • Maintain clearly written and well-organized lab notebooks, write technical reports, and contribute to regulatory filings
  • Analyze and present results in meetings
  • Interact with cell culture and purification process development, analytical, research groups and partner companies
Requirements:
  • B.S. or M.S. in Biology, Biochemistry, Chemical Engineering or related fields with 4+ years of related industrial experience or Ph.D. in related fields
  • Hands-on laboratory experience in mammalian cell line development for the production of recombinant proteins
  • Excellent critical thinking, communication, and presentation skills
  • Demonstrated ability to work independently and collaboratively in a team environment
  • Able to work in a fast paced environment with rapidly changing priorities

Please click here to submit CV/Resume (email to hr@oncomed.com) indicating the job title you are applying for.



Scientist, Cancer Biology

Description:

OncoMed Pharmaceuticals, Inc. is a clinical development-stage biopharmaceutical company focused on discovering and developing first-in-class protein therapeutics targeting cancer stem cells (CSCs) and immuno-oncology candidates. At OncoMed Pharmaceuticals, our employees are fundamental to our success; and we strive to create an atmosphere that inspires creativity, collaboration, and entrepreneurial innovation.

Job Summary:

The Department of Cancer Biology is seeking an outstanding motivated, innovative, and collaborative Scientist to design and conduct in vivo, molecular and cell biology studies to characterize the effects of novel anti-cancer stem cell and immune modulatory therapeutics. The successful candidate will be responsible for assisting the investigation of mechanisms of interplay between cancer cells and host immune system in murine tumor models. This highly interactive position will also work to collaborate with other members within and outside Cancer Biology.

Qualifications and Requirements:

All applicants should possess a Ph.D. in cancer biology, immunology, or a related field with at least 2+ years of postdoctoral academic lab or industry research experience. Responsibilities and desired techniques may include but are not limited to:

  • Strong in vivo tumor model experiments (subcutaneous and/or orthotopic xenografts)
  • Expertise in cancer and/or immunology signaling pathways
  • Mouse handling, dosing (oral gavage, IP, IV), blood, and tissue collection
  • Cell culture and immunologic assays
  • Isolation and analysis of immune cell populations by multi-color flow cytometry
  • Characterization of tumor and immune cell signaling (Western blot, functional assays)
  • Strong desire to learn and work in a dynamic environment
  • Solid publication record of innovative research
  • Excellent verbal, written, and analytical skills with the ability to adapt to changing project needs

Please click here to submit CV/Resume (email to hr@oncomed.com) indicating the job title you are applying for.



Research Associate/Senior Research Associate, Cancer Biology

Description:

OncoMed Pharmaceuticals, Inc. is a clinical development-stage biopharmaceutical company focused on discovering and developing first-in-class protein therapeutics targeting cancer stem cells (CSCs) and immuno-oncology candidates. At OncoMed Pharmaceuticals, our employees are fundamental to our success; and we strive to create an atmosphere that inspires creativity, collaboration, and entrepreneurial innovation.

Job Summary:

The Department of Cancer Biology is seeking a motivated and outstanding Research Associate/Senior Research Associate to join our efforts to execute in vivo and ex vivo studies to characterize the effects of our novel anti-CSC and immuno-oncology therapeutic molecules and their mechanisms of action. Preferred candidates will have extensive experience working with tumor mouse models, as well as hands on knowledge of cancer signaling pathways and some lab experience in immunology.

Qualifications and Requirements:

B.S. or M.S. in cancer biology, immunology, or a related field with at least 2+ years of academic lab or industry research experience (4+ years for SRA). Responsibilities and desired techniques may include but are not limited to:

  • Conducting in vivo tumor model experiments (subcutaneous and/or orthotopic xenografts)
  • Mouse handling, dosing (oral gavage, IP, IV), blood, and tissue collection
  • Bioluminescence imaging
  • Cell culture and immunologic assays
  • Immunfluorescence staining of cells and tissues
  • Isolation and analysis of immune cell populations by multi-color flow cytometry
  • Characterization of tumor and immune cell signaling (Western blot, functional assays)
  • Strong desire to learn and operate as a key team player
  • Excellent verbal, written, and analytical skills with the ability to adapt to changing project needs

Please click here to submit CV/Resume (email to hr@oncomed.com) indicating the job title you are applying for.



Manager, Regulatory Operations

Job Summary:

The Manager of Regulatory Operations will be responsible for the planning, scheduling and coordination of eCTD submissions in collaboration with internal team members/functional areas, partner companies and contract research organizations. He/she will actively participate to plan, prepare and submit electronic dossiers to FDA and/or other Health Authorities, in alignment with department and corporate goals. He/she will ensure that communications to and from North America/Global Health Authorities are archived to the appropriate databases, systems, and/or repositories.

This position will play a key role in the strategic development and implementation of Regulatory infrastructure utilizing Omnicia software, Regulatory Document Management Systems (Sharepoint), and in-house databases/ tracking tools in support of the Regulatory Affairs Department activities. This role will be integral in the continued development of processes and tools to support eCTD submissions on an ongoing basis.


Requirements:
  • Manages Microsoft Word document formatting, editing, proofing, creating and manipulating complex tables, converting text and graphics, scanning, bookmarking, hyperlinking, and Adobe Acrobat PDF rendition according to Regulatory Operations standards and/or Style Guide.
  • Supports ongoing submission activities, including (but not limited to) the assembly of regulatory submissions to US FDA in eCTD format.
  • Supports submission activities to global Health Authorities, including (but not limited to) the preparation, formatting, and QC of documents being submitted globally through CROs and Partner companies.
  • Archives all Health Authority communications received either directly or from affiliates.
  • Independently plans, prepares, reviews and submits to FDA and other appropriate Health Authorities varied regulatory filings and correspondence including annual reports and other routine submissions. Maintain and/or meet timelines and ensure content, quality, accuracy and the format of submissions comply with applicable laws, regulations and corporate standards
  • Interacts proactively with other departmental functions/teams, contract research organizations, and partner companies
  • Works effectively with regulatory and quality colleagues specializing in CMC/Manufacturing, Operations and Project Management to continuously improve regulatory systems, teamwork, and efficiency.
  • Provides accurate regulatory operations guidance and information to project management teams. Provides advice on regulatory acceptability of submission plans. Assists in establishing submission timelines and ensures timelines are met.
  • Provides strategic writing, development, and implementation of department-wide SOPs, policies and/or work processes to streamline all submission activities and standardize interactions with other departments
  • Maintains awareness and continually expands knowledge of all current, pertinent laws, regulations, guidances, policies, procedures and practices.

Qualifications:
  • BS or BA degree preferably in a scientific discipline.
  • 5-7 years experience working in pharmaceutical/biotechnology organization. 5+ years with direct experience in regulatory submissions and project coordination with demonstrated ability to interact successfully with team members and health authorities where appropriate
  • Demonstrated experience working with eCTD publishing systems and related publishing/ PDF processing tools, submission planning and document management
  • Advanced working knowledge in MS Word, MS Excel, MS PowerPoint, and Adobe Acrobat are required
  • Knowledgeable in global CTD/eCTD structure and requirements as well as industry trends for dossier preparation (INDs, CTAs, etc.).
  • Experienced with records and/or document management standards
  • Experienced with developing compatible Word templates to publishing software
  • A person who is self-motivated, well organized, detail oriented, able to prioritize, works effectively under pressure and has excellent written and verbal communication skills.
  • Experienced working with cross-functional teams and the ability to balance changing priorities and manage multiple projects
  • Familiarity with MS Project, MS Visio applications, and XML and SQL specifications is preferred
  • Demonstrated understanding of the drug development process is highly preferred
  • project management experience is highly preferred
  • Outstanding interpersonal, planning and organizational skills
  • Keen attention to detail and accuracy; able to detect errors and discrepancies, determine gaps in processes, and proactively mitigate them
  • Ability to work independently and under pressure with rapidly shifting priorities, and to prioritize workload, manage multiple projects and meet deadlines

Please click here to submit CV/Resume (email to hr@oncomed.com) indicating the job title you are applying for.



Intern, Translational Medicine

Job Summary:

The Department of Translational Medicine is seeking a motivated Intern (3 month minimum) to perform in vivo and ex vivo studies towards understanding the biology and biomarker development of our novel anti-cancer stem cell and immuno-oncology therapeutic target molecules. Preferred candidates should have an understanding of cancer biology and hands-on experience working with tumor mouse models. Additional lab experience in immunology is also highly desired.

Qualifications, responsibilities, and desired techniques may include but are not limited to:
  • B.S., M.S., or Ph.D education levels with experience and knowledge of cancer biology, cell biology, biochemistry, pharmacology, or related field
  • Hands-on experience with mouse tumor models
  • Mouse handling, dosing, and tissue collection
  • Strong desire to learn, collaborate, and operate as a team player
  • Legal authorization to work in the US

A monthly stipend is provided, based on education level. However, all housing, travel, and meals are the responsibility of the intern.

To be considered, please email a current curriculum vitae (CV), or resumé, and a cover letter that describes your interests and desired internship length to hr@oncomed.com indicating the internship you are applying for.