OncoMed Pharmaceuticals, Inc.  
 
 
 

Careers at OncoMed

  • OncoMed, a pioneer and leader in the development of novel cancer therapies directed toward tumor initiating cells, also known as “cancer stem cells”, fosters a culture of innovation as the company strives to provide significant alternatives for the treatment of cancer.

    Headquartered in Redwood City, California, our employees bring a passionate dedication to the advancement of novel treatments for patients with cancer.

Open Positions:



Research Associate/Senior Research Associate

Description:

Job Summary OncoMed is seeking an outstanding Research associate/Senior research associate to join work on the discovery of novel approaches to target cancer via regulation of immune surveillance. Successful candidate will assist investigating mechanisms of interplay between cancer cells and host immune system in murine tumor models, and collaborate with others within the group and throughout the company on the discovery and development of therapeutic proteins and antibodies to novel cancer stem cell targets.


Requirements:
  • BS or MS degree in Immunology, Biology, Life Sciences or other related filed
  • Strong desire to work in a dynamic collaborative environment and learn new things
  • Strong ex vivo skills on functional immunological assays including ELISPOT, T and NK cell Cytotoxicity, Treg/MDSC suppression assays
  • Strong in vitro skills including but not limited to tissue culture, molecular biology (RNA/DNA isolation, clonining, and gene expression analysis, etc) , and protein analysis (ELISA, lmmunoprecipitation, and Western Blotting, etc)
  • In vivo skills including various dosing and surgery in rodents
  • Isolation of various cell populations from mice and ex vivo characterization
  • Ability to multitask and thrive in a fast-paced and challenging environment
  • Excellent oral/written communication and interpersonal skills
  • Good lab notebook recording

Submit CV/Resume



Contract SAS Programmer

Description:

Job Summary OncoMed Pharmaceuticals is a development-stage biotechnology company dedicated to improving cancer treatment by discovering and developing monoclonal antibodies and other agents that target the biologic pathways critical to tumor initiating cells, also known as "cancer stem cells". We are leveraging our understanding of these tumor initiating cells to discover and develop novel therapeutics that could provide important alternatives for the treatment of cancer.
This position involves programming analysis data sets, tables, listings and graphs using SAS to support the ongoing Phase 1 and 2 clinical trial activities for several molecules as well as programming to verify the accuracy of table outputs received from CROs or generated in house. Some statistical training is desirable but not required. Experience in creating graphs using SAS graph and R is desirable . This position is a half time contract position.


Requirements:
  • Masters Degree in Statistics, Computer Science, Mathematics or related discipline
  • Strong Working knowledge of SAS
  • Minimum of 5 years of clinical trial programming experience with SAS in the biotechnology, or pharmaceutical industry
  • Self motivated, able to work independently, team player

Submit CV/Resume



Director, Analytical Sciences

Description:

Job Summary The successful candidate for Director will be responsible for managing the Analytical Sciences group. Key responsibilities of the group are methods development, qualification and technology transfer activities, protein characterization, and analytical support for process development including stability studies, to enable pre-clinical and clinical development of monoclonal antibodies and fusion proteins. The Director will be responsible for managing and supervising a team of employees, and setting priorities for the Analytical Sciences group to meet project timelines. The Director will be a key member of the Process Development and Manufacturing team and will closely collaborate with OncoMed Research, Process Sciences, Regulatory Affairs and Quality Operations as well as with our external partners, CRO’s and CMO’s. The Director is also responsible for the quality and timeliness of analytical documents, including SOPs, technical reports, assay qualification reports and Regulatory submissions.


Requirements:
  • Ph.D. in Chemistry, Biochemistry, Biology, Immunology, or related field
  • A Ph.D. and a minimum of 8 years industry experience is required, preferably in a biotechnology / biopharmaceutical environment
  • Experience in managing an Analytical Development Group
  • Expert in developing biophysical assays for characterization of monoclonal antibodies and other proteins
  • Experience with electrophoresis, HPLC and mass spectrometry
  • Proficient in analytical techniques including immunoassays and other plate based assays
  • Familiarity with GMP and GLP regulatory and industry guidance documents for drug development and product characterization
  • Experience in technology transfer
  • Experience with data management systems and statistical software
  • Demonstrated ability to work in a team and fast paced environment
  • Excellent written and verbal communication skills

Submit CV/Resume



Senior Patent Counsel

Description:

Job Summary OncoMed Pharmaceuticals, a clinical-stage biotechnology company pioneering the development of novel therapeutics that target cancer stem cells, is seeking a senior patent attorney to join its legal team. In general, the Senior Patent Counsel will be responsible for the preparation, filing and prosecution of patent applications, formulating patent strategy, and conducting patentability and freedom-to-operate evaluations for designated research and development programs. Other responsibilities will include counseling management and scientists on patent-related matters. The Senior Patent Counsel will report to OncoMed’s Vice President and General Counsel.


Responsibilities:
  • Maintain the U.S. and foreign patent application prosecution docket for designated research and development programs
  • Formulate patent strategy and counsel management and scientists on patent matters including patent strategies for designated research and development programs, taking into account relevant obligations under research collaboration or license agreements and third-party patent issues
  • Identify inventions and draft, file, and prosecute patent applications on the inventions
  • Analyze third-party patents and prepare legal opinions regarding patentability, validity and freedom to operate
  • Direct outside counsel prosecution and opinion services
  • Conduct IP due diligence assessments and/or manage IP due diligence requests from third parties in support of the company’s business development activities
  • Review and provide input on IP matters for agreements
  • Communicate effectively with counsel for the company’s partners, licensors, and licensees regarding patent matters
  • Assist with the preparation and filing of applications for the company’s trademarks and manage the company’s trademark docket
  • Review external publication requests

Requirements:
  • At least 5 years experience in preparation and prosecution of biotech patent applications in a biotech or pharma therapeutics corporate setting and/or in a law firm servicing such clients
  • Admission to practice before the U.S. Patent and Trademark Office
  • A law degree (J.D.) from an ABA-accredited law school
  • Member in good standing of a state bar (State Bar of California preferred), and if not a member of the State Bar of California, must be eligible to be registered with the State Bar of California as Registered In-House Counsel
  • An advanced degree in a relevant scientific discipline (e.g., Biology, Biochemistry, Molecular Biology), with a Ph.D. strongly preferred
  • Experience with the preparation of infringement, validity, and freedom-to-operate opinions and counseling clients regarding patentability and freedom to operate
  • Strong analytical and critical thinking skills and sound decision-making abilities
  • Excellent written and verbal communication skills in English
  • Technical expertise and/or patent prosecution experience in the area of oncology, antibodies, cancer biology, stem cell biology and/or immunology is strongly preferred

Submit CV/Resume



2015 OncoMed Research Internship Program

Description:

Job Summary OncoMed Pharmaceuticals, Inc. is a clinical development-stage biopharmaceutical company focused on discovering and developing first-in-class protein therapeutics targeting cancer stem cells. The OncoMed Summer Research Internship Program was created to introduce undergraduate and graduate level students to careers in stem cell, bioinformatics, process development, and protein chemistry research in the biotechnology industry. Our internship program provides motivated students with an outstanding training environment that fosters creativity and learning in the following areas:


  • Target identification and validation
  • Cancer stem cell biology
  • Immunology/Immunotherapy
  • Protein and antibody engineering
  • Process and bioanalytical development
  • In-vivo biology
  • Translational Medicine
  • Bioinformatics and Diagnostics
  • Pharmacokinetics and Pharmacometrics

Summer internships at OncoMed last approximately 3 months and are open to undergraduate and graduate-level (MS, PhD) students between May and September. For exceptional candidates, internship may be extended at the discretion of the mentor and Program Directors. Interns will work alongside individual Scientists and attend group research meetings and seminars. In addition, interns will present their work at the conclusion of the program. All housing, travel, and meals are the responsibility of the intern.


Code   Research Area
  • SI-1    Molecular Biology/Target identification and validation
  • SI-2    In vivo Cancer Biology
  • SI-3    Immunology/Immunotherapy
  • SI-4    Process and Bioanalytical development
  • SI-5    Translational Medicine
  • SI-6    Bioinformatics and Diagnostics
  • SI-7    Pharmacokinetics and Pharmacometrics

To be considered, please email a current curriculum vitae (CV) or résumé and cover letter that describes your interests and desired internship length to hr@oncomed.com Please include the research area of interest reference code(s) when applying (multiple selections are allowed)

Applications must be received no later than March 31, 2015, for consideration.



Clinical Scientist or Senior Clinical Scientist, Oncology (PhD or equivalent)

Description:

Job Summary OncoMed is a clinical-stage company focused on discovering and developing novel therapeutics targeting cancer stem cells (CSCs). OncoMed has six anti-cancer product candidates in clinical development, including demcizumab (Anti-DLL4, OMP-21M18), OMP-305B83 (bispecific for Anti-DLL4 and Anti-VEGF), tarextumab (Anti-Notch2/3, OMP-59R5), OMP-52M51 (Anti-Notch1), vantictumab (Anti-FZD7, OMP-18R5), and ipafricept (OMP-54F28; Fzd8-Fc), that target key cancer stem cell signaling pathways including Notch and Wnt. OncoMed has additional antibodies and small molecules in preclinical development with Investigational New Drug filings planned as early as 2015 (including an anti-RSPO3 antibody IND filing in the first half of 2015). OncoMed is also pursuing discovery of additional novel anti-CSC and Immuno-Oncology product candidates.

OncoMed is seeking a talented and highly motivated individual to join the expanding and dynamic Clinical Development team. The ideal candidate should have extensive experience in biotechnology and a proven track record in the clinical development of Oncology drug candidates. The (Senior) Clinical Scientist will be involved in one or more clinical programs from first-in-human to proof-of-concept studies. Additionally, OncoMed has the ability to take drug candidates through registration and commercialization, making future Phase 3 and 4 development another potential activity. The (Senior) Clinical Scientist will collaborate closely with the Medical Director(s) of the clinical program(s), the Translational Research and Biomarker groups, as well as Clinical Operations, Biostatistics and Regulatory groups and be involved in the science-driven design, implementation, monitoring, analysis and reporting of clinical studies. Opportunities to contribute and present to investigator meetings and advisory boards, as well as contributing to publication plans, will also be available to the (Senior) Clinical Scientist.


Responsibilities:
  • Closely collaborate with Medical Directors and other clinical team members to implement and analyze science-driven clinical studies
  • Closely interact with the Translational Research and Biomarker groups to implement and analyze biomarker strategies for science-driven clinical studies
  • Contribute to the design, execution and completion of Phase 1a, Phase 1b and/or Phase 2 trials, as well as future Phase 3 and 4 trials
  • Monitor data from ongoing clinical studies with strong emphasis on safety
  • Perform data analysis of clinical trials, report results and write clinical study reports
  • Contribute to the authoring and review of regulatory documents (Annual Report, Investigator Brochure, responses to information requests, etc.)
  • Establish and maintain excellent relationships with clinical investigators and CRO staff
  • Contribute to the selection and oversight of CROs
  • As needed for the stage of the clinical program, travel to study sites, CRO partners, medical meetings, advisory boards, etc.

Requirements:
  • Advanced degree in Life Sciences (PhD or equivalent)
  • Minimum of 4 years of biotech/pharmaceutical industry experience, minimum of 2 years of related clinical drug development experience
  • Experience in Oncology preferred
  • Ability to evaluate, interpret and present complex scientific data
  • Knowledge of legal and regulatory requirements (GCP and ICH guidelines)
  • Ability to build and maintain relationships with clinical collaborators
  • Collaborative spirit
  • Excellent verbal and written communication skills
  • Strong organizational skills
  • Proficiency with standard Office software packages (Microsoft Word, Powerpoint, Excel)

Submit CV/Resume



Intern, Cancer Biology

Description:

Job Summary The Cancer Biology Department is seeking a highly motivated, hard-working and reliable intern at the Ph.D. level to join the research team. The successful candidate will play an important role in existing oncology drug discovery projects, focusing on investigating the mechanism of action of OncoMed’s lead antibody therapeutics at the cellular and molecular level, and working with members of Translational Medicine to discover and validate biomarkers indicative of response to OncoMed’s lead antibodies. This position offers an excellent opportunity for an individual to work on cutting edge cancer research in a dynamic team environment.


Requirements:
  • Ph.D. student or postdoc with experience in cancer biology or related field
  • Hands-on experience in mouse models of cancer and in vivo animal handling procedures are required
  • Experience with cellular and molecular techniques including RNA isolation, cDNA synthesis, qPCR, ELISA, Western blot and immunohistochemistry
  • Strong work ethic and ability to work effectively as part of a team

Submit CV/Resume



Senior Associate/Manager Regulatory Affairs

Description:

Job Summary The Senior Associate/Manager will plan, prepare and submit to FDA and other appropriate Health Authorities (in collaboration with internal team members/functional areas, partner companies and contract research organizations) varied regulatory filings and correspondence. They will lead and manage the process in support of regulatory objectives, advice and strategy in alignment with department and corporate goals. The candidate will keep abreast of evolving regulatory procedures and practices. This role is responsible for execution of assigned projects through the ability to work independently with guidance from direct manager, ability to multitask as well as the ability both lead and be an active team member.

Duties & Responsibilities: The Senior Associate/Manager, under limited supervision, will be responsible for managing and overseeing the coordination, compilation and submission of regulatory documentation to health agencies and will support day to day regulatory operations.

Responsibilities:

  • Independently plans, prepares, reviews and submits to FDA and other appropriate Health Authorities varied regulatory filings and correspondence including annual reports and other routine submissions. Maintain and/or meet timelines and ensure content, quality, accuracy and the format of submissions comply with applicable laws, regulations and corporate standards
  • Interfaces and communicates effectively with cross-functional team members and management on a regular basis to ensure projectspecific regulatory strategy, process and timelines are met
  • Supports product development teams by interpreting and strategically applying regulations, guidances and available research/information to submission and product related work
  • Interacts proactively with other departmental functions/teams, contract research organizations, and partner companies
  • Ensures that all submission documentation, record keeping and reporting remain in compliance with regulatory filings and in accordance with current regulatory requirements
  • Works effectively with regulatory and quality colleagues specializing in CMC/Manufacturing and Operations to continuously improve regulatory systems, teamwork, and efficiency
  • Contributes to improvements in department operating procedures
  • Conducts regulatory intelligence for products in research and development
  • Maintains awareness of all current, pertinent regulations, guidances, policies, procedures and practices
  • Analyzes changes and updates and advises and provides recommendations to the department and interested personnel as needed

Competencies:
  • Collaborative, team player with a positive attitude and creative problem solving abilities
  • Effective communication (written and verbal) and influencing skills
  • Ability to clearly and effectively communicate ideas, data, and concepts, while adjusting one's style based upon the audience
  • Keen attention to detail; able to detect errors and discrepancies, determine gaps in processes, and proactively mitigate them
  • Works effectively in a multi-task environment
  • Knows and uses strong planning and organization skills and practices
  • Keeps track of information and activities, monitors progress, follows up and reports outcomes as needed

Requirements:
  • BS or BA degree preferably in a scientific discipline
  • 3-7 years experience working in pharmaceutical/biotechnology organization with direct experience in regulatory affairs
  • Expert project management and interpersonal skills, as well as excellent written and verbal communication ability
  • Experience working with electronic submission platforms, eCTD and submission planning is required
  • Knowledge of applicable and evolving US regulations, guidelines, and/or specifications
  • Experience in interpretation of regulations, guidelines and precedents related to drug development
  • A person who is self-motivated, well organized, detail oriented, able to prioritize, works effectively under pressure and has excellent written and verbal communication skills
  • The ability to manage multiple projects is required
  • Experience working with cross-functional teams and the ability to balance changing priorities is required

Submit CV/Resume