OncoMed Pharmaceuticals, Inc.  
 
 
 

Careers at OncoMed

  • OncoMed, a pioneer and leader in the development of novel cancer therapies directed toward tumor initiating cells, also known as “cancer stem cells”, fosters a culture of innovation as the company strives to provide significant alternatives for the treatment of cancer.

    Headquartered in Redwood City, California, our employees bring a passionate dedication to the advancement of novel treatments for patients with cancer.

Open Positions:



Biomarker Scientist –Translational Medicine

Description:

Job Summary We are looking for a highly motivated collaborative Scientist that enjoys working in a fast paced work environment. The successful candidate will play an essential role in OncoMed’s Translational Medicine Group working on pharmacodynamic and predictive biomarker studies in support of OncoMed’s clinical pipeline. The candidate will closely collaborate with the Clinical Development and the Research teams.


Responsibilities:
  • Individual contribution including direct hands-on biomarker assay development, validation, and analysis to support clinical programs
  • Provide support for OncoMed’s clinical biomarker operations, including clinical sample management and protocol writing
  • Identify and develop pharmacodynamic markers to assess and distinguish clinical drug effects
  • Contribute to developing strategies and assays around the use of Predictive Medicine technologies for oncology and immuno-oncology drug development

Requirements:
  • Ph.D. with at least 2 years pharmaceutical industry experience
  • Experience in the application of biomarkers towards oncology and immuno-oncology drug development is preferred
  • Proficiency with qRT-PCR, FACS, ELISA, tissue culture
  • Experience with the discovery and development of predictive biomarkers and pharmacodynamic biomarkers is strongly preferred
  • Experience in handling clinical specimens, including tissue samples and plasma is required
  • Experience managing projects with CROs preferred
  • Excellent skills in written and oral communication are required
  • Works well and thrives in a matrix environment, collaborating with Research and Clinical teams

Submit CV/Resume



Research Associate/Senior Research Associate

Description:

Job Summary OncoMed is seeking an outstanding Research associate/Senior research associate to join work on the discovery of novel approaches to target cancer via regulation of immune surveillance. Successful candidate will assist investigating mechanisms of interplay between cancer cells and host immune system in murine tumor models, and collaborate with others within the group and throughout the company on the discovery and development of therapeutic proteins and antibodies to novel cancer stem cell targets.


Requirements:
  • BS or MS degree in Immunology, Biology, Life Sciences or other related filed
  • Strong desire to work in a dynamic collaborative environment and learn new things
  • Strong ex vivo skills on functional immunological assays including ELISPOT, T and NK cell Cytotoxicity, Treg/MDSC suppression assays
  • Strong in vitro skills including but not limited to tissue culture, molecular biology (RNA/DNA isolation, clonining, and gene expression analysis, etc) , and protein analysis (ELISA, lmmunoprecipitation, and Western Blotting, etc)
  • In vivo skills including various dosing and surgery in rodents
  • Isolation of various cell populations from mice and ex vivo characterization
  • Ability to multitask and thrive in a fast-paced and challenging environment
  • Excellent oral/written communication and interpersonal skills
  • Good lab notebook recording

Submit CV/Resume



Contract SAS Programmer

Description:

Job Summary OncoMed Pharmaceuticals is a development-stage biotechnology company dedicated to improving cancer treatment by discovering and developing monoclonal antibodies and other agents that target the biologic pathways critical to tumor initiating cells, also known as "cancer stem cells". We are leveraging our understanding of these tumor initiating cells to discover and develop novel therapeutics that could provide important alternatives for the treatment of cancer.
This position involves programming analysis data sets, tables, listings and graphs using SAS to support the ongoing Phase 1 and 2 clinical trial activities for several molecules as well as programming to verify the accuracy of table outputs received from CROs or generated in house. Some statistical training is desirable but not required. Experience in creating graphs using SAS graph and R is desirable . This position is a half time contract position.


Requirements:
  • Masters Degree in Statistics, Computer Science, Mathematics or related discipline
  • Strong Working knowledge of SAS
  • Minimum of 5 years of clinical trial programming experience with SAS in the biotechnology, or pharmaceutical industry
  • Self motivated, able to work independently, team player

Submit CV/Resume



Director, Analytical Sciences

Description:

Job Summary The successful candidate for Director will be responsible for managing the Analytical Sciences group. Key responsibilities of the group are methods development, qualification and technology transfer activities, protein characterization, and analytical support for process development including stability studies, to enable pre-clinical and clinical development of monoclonal antibodies and fusion proteins. The Director will be responsible for managing and supervising a team of employees, and setting priorities for the Analytical Sciences group to meet project timelines. The Director will be a key member of the Process Development and Manufacturing team and will closely collaborate with OncoMed Research, Process Sciences, Regulatory Affairs and Quality Operations as well as with our external partners, CRO’s and CMO’s. The Director is also responsible for the quality and timeliness of analytical documents, including SOPs, technical reports, assay qualification reports and Regulatory submissions.


Requirements:
  • Ph.D. in Chemistry, Biochemistry, Biology, Immunology, or related field
  • A Ph.D. and a minimum of 8 years industry experience is required, preferably in a biotechnology / biopharmaceutical environment
  • Experience in managing an Analytical Development Group
  • Expert in developing biophysical assays for characterization of monoclonal antibodies and other proteins
  • Experience with electrophoresis, HPLC and mass spectrometry
  • Proficient in analytical techniques including immunoassays and other plate based assays
  • Familiarity with GMP and GLP regulatory and industry guidance documents for drug development and product characterization
  • Experience in technology transfer
  • Experience with data management systems and statistical software
  • Demonstrated ability to work in a team and fast paced environment
  • Excellent written and verbal communication skills

Submit CV/Resume



Senior Associate/Manager Regulatory Affairs

Description:

Job Summary The Senior Associate/Manager will plan, prepare and submit to FDA and other appropriate Health Authorities (in collaboration with internal team members/functional areas, partner companies and contract research organizations) varied regulatory filings and correspondence. They will lead and manage the process in support of regulatory objectives, advice and strategy in alignment with department and corporate goals. The candidate will keep abreast of evolving regulatory procedures and practices. This role is responsible for execution of assigned projects through the ability to work independently with guidance from direct manager, ability to multitask as well as the ability both lead and be an active team member.

Duties & Responsibilities: The Senior Associate/Manager, under limited supervision, will be responsible for managing and overseeing the coordination, compilation and submission of regulatory documentation to health agencies and will support day to day regulatory operations.

Responsibilities:

  • Independently plans, prepares, reviews and submits to FDA and other appropriate Health Authorities varied regulatory filings and correspondence including annual reports and other routine submissions. Maintain and/or meet timelines and ensure content, quality, accuracy and the format of submissions comply with applicable laws, regulations and corporate standards
  • Interfaces and communicates effectively with cross-functional team members and management on a regular basis to ensure projectspecific regulatory strategy, process and timelines are met
  • Supports product development teams by interpreting and strategically applying regulations, guidances and available research/information to submission and product related work
  • Interacts proactively with other departmental functions/teams, contract research organizations, and partner companies
  • Ensures that all submission documentation, record keeping and reporting remain in compliance with regulatory filings and in accordance with current regulatory requirements
  • Works effectively with regulatory and quality colleagues specializing in CMC/Manufacturing and Operations to continuously improve regulatory systems, teamwork, and efficiency
  • Contributes to improvements in department operating procedures
  • Conducts regulatory intelligence for products in research and development
  • Maintains awareness of all current, pertinent regulations, guidances, policies, procedures and practices
  • Analyzes changes and updates and advises and provides recommendations to the department and interested personnel as needed

Competencies:
  • Collaborative, team player with a positive attitude and creative problem solving abilities
  • Effective communication (written and verbal) and influencing skills
  • Ability to clearly and effectively communicate ideas, data, and concepts, while adjusting one's style based upon the audience
  • Keen attention to detail; able to detect errors and discrepancies, determine gaps in processes, and proactively mitigate them
  • Works effectively in a multi-task environment
  • Knows and uses strong planning and organization skills and practices
  • Keeps track of information and activities, monitors progress, follows up and reports outcomes as needed

Requirements:
  • BS or BA degree preferably in a scientific discipline
  • 3-7 years experience working in pharmaceutical/biotechnology organization with direct experience in regulatory affairs
  • Expert project management and interpersonal skills, as well as excellent written and verbal communication ability
  • Experience working with electronic submission platforms, eCTD and submission planning is required
  • Knowledge of applicable and evolving US regulations, guidelines, and/or specifications
  • Experience in interpretation of regulations, guidelines and precedents related to drug development
  • A person who is self-motivated, well organized, detail oriented, able to prioritize, works effectively under pressure and has excellent written and verbal communication skills
  • The ability to manage multiple projects is required
  • Experience working with cross-functional teams and the ability to balance changing priorities is required

Submit CV/Resume