OncoMed Pharmaceuticals, Inc.  
 
 
 

Careers at OncoMed

  • OncoMed, a pioneer and leader in the development of novel cancer therapies directed toward tumor initiating cells, also known as “cancer stem cells”, fosters a culture of innovation as the company strives to provide significant alternatives for the treatment of cancer.

    Headquartered in Redwood City, California, our employees bring a passionate dedication to the advancement of novel treatments for patients with cancer.

Open Positions:



Sr. Scientist, Cell Line Development

Description:

Job Summary The Process Sciences Department in OncoMed is seeking a creative, highly motivated and experienced individual with expertise in molecular and cellular biology. The Sr. Scientist will play an integral role as a key member of the group focused on the development and characterization of high productivity CHO cell lines for biologics production.


Responsibilities:
  • Responsible for delivering commercial-ready recombinant protein expressing stable cell lines to meet CMC project timelines to clinic
  • Lead the CLD group to characterize production cell line with high productivity, quality and stability
  • Author relevant sections of regulatory submission and serve as cell line/cell bank SME in key regulatory interactions
  • Perform aseptic cell culture of CHO cell lines, transfection and selection of stable cell lines, single cell cloning, cell banking and evaluation of clonal cell lines for stability, productivity and quality
  • Collaborate closely with other Process Development team members and contribute to experimental designs and interpretation
  • Properly document work, write development reports, present findings in team meetings and contribute to discussions
  • Build productive relationships with Project management, Analytical, Quality and Research

Requirements:
  • PhD or MS in Molecular Genetics, Cell Biology, Biochemistry, or related fields with 5+ years of experience in mammalian expression technology development in the biotech industry
  • Experience in optimizing all aspects of cell line development processes
  • Hands on laboratory experience in stable cell line generation for both research and manufacturing cell lines
  • Strong understanding of approaches used to evaluate clonal cell line stability at the cell culture and genetic level
  • Knowledge of current approaches to verify cell line clonality and associated verification methods
  • Critical thinking, excellent communication and presentation skills
  • Highly organized and pays attention to details
  • Excellent interpersonal skills and highly collaborative
  • Able to work in a fast paced environment with rapidly changing priorities
  • Demonstrated ability to supervise direct report and work effectively on cross functional teams, and rapidly adapt technologies and processes to meet the needs of a growing pipeline
  • Experience in Ambr operation and cell culture process development a plus

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Sr. Manager, Technical Accounting

Description:

Job Summary OncoMed is seeking a high-performing, business professional to join its Finance organization. The position reports to the Sr. Director, Finance and will be a key force in driving OncoMed to the next level in SOX compliance, SEC reporting, technical accounting, equity accounting / stock administration, and tax. This individual must be a highly motivated, self-starter with strong technical accounting and analytical skills. The successful candidate will be hands-on, proactive, and driven by tackling challenging problems and delivering meaningful, yet practical, solutions.


Responsibilities:
  • Manage annual audit and quarterly reviews with external auditors, including fieldwork, audit interactions and PBC preparations
  • Serve as subject matter expert on US GAAP and SEC regulations. Research new accounting standards and technical accounting issues. Prepare white papers and technical accounting memos summarizing technical accounting issues and application of accounting guidance to the Company
  • Prepare and assist in management of SEC reporting requirements. Responsible for consolidated financial statements, footnotes, and MD&A for Forms 10-Q, 10-K, and proxy as well as financial information related to the quarterly press releases, including all relevant supporting schedules
  • Manage the SOX compliance program and coordinate with finance team and external SOX service provider for phased implementation of SOX 404 requirements
  • Thought leader and process owner of equity accounting and stock administration
  • Interact with external tax advisors to address the Company’s tax needs, including reviewing the annual tax provision, overseeing the preparation of the annual tax filings, and addressing other tax-related requirements and issues, e.g. Section 382 study, R&D Tax Credit study, etc
  • Own key aspects of month-end financial close and financial reporting. Assist in day-to-day technical financial accounting activities
  • Participate in special finance and systems projects

Requirements:
  • BS/BA in Business/Accounting (or related field), CPA required
  • Strong technical accounting and analytical skills required
  • 5 to 7 years of public accounting experience (Big Four experience preferred); additional experience in life science industry desirable
  • Problem solver, action-oriented, and process improvement-minded
  • Self-starter, adaptable and collaborative team player
  • Excellent written and verbal communication skills

Submit CV/Resume



Sr. Manager/ Associate Director, Project Management

Description:

Job Summary OncoMed Pharmaceuticals is developing novel biologic therapies for the treatment of cancer and currently has 7 clinical stage product candidates. This position reports to the CMC Team Leader. OncoMed seeks an outstanding Project Manager at the Sr. Manager/Associate Director level who is looking to make a substantial impact on the delivery of CMC activities.


Responsibilities:
  • Maintain and monitor project schedules for Phase 1-3 activities
  • Track completion of project deliverables from Process Development, Manufacturing, Quality and Supply Chain
  • Identify and highlight critical decision points, events and milestones
  • Develop and publish project reporting including appropriate risk analysis
  • Maintain risk registers for all CMC development programs
  • Communicate changes to project plans in a proactive and clear manner
  • Facilitate key internal and external meetings, including meeting agendas and minutes
  • Support the development of project goals and expectations
  • Prepare and support the external manufacturing budget

Requirements:
  • BS/ MS in a scientific/engineering field and 10+ years of experience; final level will be commensurate with candidate’s experience
  • A minimum of 3 years as a Project Manager, with previous experience in Process Development, Manufacturing or Quality
  • Project Management coursework desired, PMP certification preferred
  • Must be organized and communicate well
  • Strong ability to influence outcomes without direct authority and ability to hold oneself and others accountable for commitments
  • Track record of successfully working in cross-functional teams and projects
  • Strong skill set with Microsoft Project
  • Experience working with external manufacturing vendors and partners is preferred

Submit CV/Resume



Clinical Scientist or Senior Clinical Scientist, Oncology

Description:

Job Summary OncoMed is a clinical-stage company focused on discovering and developing novel therapeutics targeting cancer stem cells (CSCs). OncoMed has six anti-cancer product candidates in clinical development, including demcizumab (Anti-DLL4, OMP-21M18), OMP-305B83 (bispecific for Anti-DLL4 and Anti-VEGF), tarextumab (Anti-Notch2/3, OMP-59R5), OMP-52M51 (Anti-Notch1), vantictumab (Anti-FZD7, OMP-18R5), and ipafricept (OMP-54F28; Fzd8-Fc), that target key cancer stem cell signaling pathways including Notch and Wnt. OncoMed has additional antibodies and small molecules in preclinical development with Investigational New Drug filings planned as early as 2015 (including an anti-RSPO3 antibody IND filing in the first half of 2015). OncoMed is also pursuing discovery of additional novel anti-CSC and Immuno-Oncology product candidates.

OncoMed is seeking a talented and highly motivated individual to join the expanding and dynamic Clinical Development team. The ideal candidate should have extensive experience in biotechnology and a proven track record in the clinical development of Oncology drug candidates. The (Senior) Clinical Scientist will be involved in one or more clinical programs from first-in-human to proof-of-concept studies. Additionally, OncoMed has the ability to take drug candidates through registration and commercialization, making future Phase 3 and 4 development another potential activity. The (Senior) Clinical Scientist will collaborate closely with the Medical Director(s) of the clinical program(s), the Translational Research and Biomarker groups, as well as Clinical Operations, Biostatistics and Regulatory groups and be involved in the science-driven design, implementation, monitoring, analysis and reporting of clinical studies. Opportunities to contribute and present to investigator meetings and advisory boards, as well as contributing to publication plans, will also be available to the (Senior) Clinical Scientist.


Responsibilities:
  • Closely collaborate with Medical Directors and other clinical team members to implement and analyze science-driven clinical studies
  • Closely interact with the Translational Research and Biomarker groups to implement and analyze biomarker strategies for science-driven clinical studies
  • Contribute to the design, execution and completion of Phase 1a, Phase 1b and/or Phase 2 trials, as well as future Phase 3 and 4 trials
  • Monitor data from ongoing clinical studies with strong emphasis on safety
  • Perform data analysis of clinical trials, report results and write clinical study reports
  • Contribute to the authoring and review of regulatory documents (Annual Report, Investigator Brochure, responses to information requests, etc.)
  • Establish and maintain excellent relationships with clinical investigators and CRO staff
  • Contribute to the selection and oversight of CROs
  • As needed for the stage of the clinical program, travel to study sites, CRO partners, medical meetings, advisory boards, etc.

Requirements:
  • Advanced degree in Life Sciences (PhD or equivalent)
  • Minimum of 4 years of biotech/pharmaceutical industry experience, minimum of 2 years of related clinical drug development experience
  • Experience in Oncology preferred
  • Ability to evaluate, interpret and present complex scientific data
  • Knowledge of legal and regulatory requirements (GCP and ICH guidelines)
  • Ability to build and maintain relationships with clinical collaborators
  • Collaborative spirit
  • Excellent verbal and written communication skills
  • Strong organizational skills
  • Proficiency with standard Office software packages (Microsoft Word, Powerpoint, Excel)

Submit CV/Resume



Scientist - Cancer Biology

Description:

Job Summary OncoMed is seeking a motivated Scientist to join the Cancer Biology group to evaluate the effect of novel cancer therapeutic agents targeting cancer stem cells and promoting anti-tumor immunity in preclinical tumor models. The Scientist will be responsible for the design and execution of preclinical studies and ex vivo analyses focused on the following:


Responsibilities:
  • The extent to which both approved and novel immunotherapeutic agents can be combined with anti-cancer stem cell therapies to effect lasting anti-tumor responses
  • Elucidation of the mechanisms of action of OncoMed therapeutics
  • Discovery of predictive and pharmacodynamic biomarkers for ongoing and future clinical stage agents

Requirements:
  • PhD or equivalent degree with a minimum of 2 years post-doctoral experience in cancer biology or immuno-oncology
  • Extensive experience with preclinical tumor models, preferably both patient-derived xenograft and immunocompetent models
  • Expertise in FACS
  • Experience with standard cell culture, molecular biology and protein biochemistry techniques
  • Strong motivation, creativity, independence, and ability to work in a dynamic collaborative environment
  • Excellent written and oral communication skills
  • Preference will be given to candidates with experience in ex vivo functional immunological assays

Submit CV/Resume



Biomarker Scientist – Translational Medicine

Description:

Job Summary We are looking for a highly motivated collaborative Scientist that enjoys working in a fast paced work environment. The successful candidate will play an essential role in OncoMed’s Translational Medicine Group working on pharmacodynamic and predictive biomarker studies in support of OncoMed’s clinical pipeline. The candidate will closely collaborate with the Clinical Development and the Research teams.


Responsibilities:
  • Individual contribution including direct hands-on biomarker assay development, validation, and analysis to support clinical programs
  • Provide support for OncoMed’s clinical biomarker operations, including clinical sample management and protocol writing
  • Identify and develop pharmacodynamic markers to assess and distinguish clinical drug effects
  • Contribute to developing strategies and assays around the use of Predictive Medicine technologies for oncology and immuno-oncology drug development

Requirements:
  • Ph.D. with at least 2 years pharmaceutical industry experience
  • Experience in the application of biomarkers towards oncology and immuno-oncology drug development is preferred
  • Proficiency with qRT-PCR, FACS, ELISA, tissue culture
  • Experience with the discovery and development of predictive biomarkers and pharmacodynamic biomarkers is strongly preferred
  • Experience in handling clinical specimens, including tissue samples and plasma is required
  • Experience managing projects with CROs preferred
  • Excellent skills in written and oral communication are required
  • Works well and thrives in a matrix environment, collaborating with Research and Clinical teams

Submit CV/Resume



Research Associate/Senior Research Associate

Description:

Job Summary OncoMed is seeking an outstanding Research associate/Senior research associate to join work on the discovery of novel approaches to target cancer via regulation of immune surveillance. Successful candidate will assist investigating mechanisms of interplay between cancer cells and host immune system in murine tumor models, and collaborate with others within the group and throughout the company on the discovery and development of therapeutic proteins and antibodies to novel cancer stem cell targets.


Requirements:
  • BS or MS degree in Immunology, Biology, Life Sciences or other related filed
  • Strong desire to work in a dynamic collaborative environment and learn new things
  • Strong ex vivo skills on functional immunological assays including ELISPOT, T and NK cell Cytotoxicity, Treg/MDSC suppression assays
  • Strong in vitro skills including but not limited to tissue culture, molecular biology (RNA/DNA isolation, clonining, and gene expression analysis, etc) , and protein analysis (ELISA, lmmunoprecipitation, and Western Blotting, etc)
  • In vivo skills including various dosing and surgery in rodents
  • Isolation of various cell populations from mice and ex vivo characterization
  • Ability to multitask and thrive in a fast-paced and challenging environment
  • Excellent oral/written communication and interpersonal skills
  • Good lab notebook recording

Submit CV/Resume



Contract SAS Programmer

Description:

Job Summary OncoMed Pharmaceuticals is a development-stage biotechnology company dedicated to improving cancer treatment by discovering and developing monoclonal antibodies and other agents that target the biologic pathways critical to tumor initiating cells, also known as "cancer stem cells". We are leveraging our understanding of these tumor initiating cells to discover and develop novel therapeutics that could provide important alternatives for the treatment of cancer.
This position involves programming analysis data sets, tables, listings and graphs using SAS to support the ongoing Phase 1 and 2 clinical trial activities for several molecules as well as programming to verify the accuracy of table outputs received from CROs or generated in house. Some statistical training is desirable but not required. Experience in creating graphs using SAS graph and R is desirable . This position is a half time contract position.


Requirements:
  • Masters Degree in Statistics, Computer Science, Mathematics or related discipline
  • Strong Working knowledge of SAS
  • Minimum of 5 years of clinical trial programming experience with SAS in the biotechnology, or pharmaceutical industry
  • Self motivated, able to work independently, team player

Submit CV/Resume



Director, Analytical Sciences

Description:

Job Summary The successful candidate for Director will be responsible for managing the Analytical Sciences group. Key responsibilities of the group are methods development, qualification and technology transfer activities, protein characterization, and analytical support for process development including stability studies, to enable pre-clinical and clinical development of monoclonal antibodies and fusion proteins. The Director will be responsible for managing and supervising a team of employees, and setting priorities for the Analytical Sciences group to meet project timelines. The Director will be a key member of the Process Development and Manufacturing team and will closely collaborate with OncoMed Research, Process Sciences, Regulatory Affairs and Quality Operations as well as with our external partners, CRO’s and CMO’s. The Director is also responsible for the quality and timeliness of analytical documents, including SOPs, technical reports, assay qualification reports and Regulatory submissions.


Requirements:
  • Ph.D. in Chemistry, Biochemistry, Biology, Immunology, or related field
  • A Ph.D. and a minimum of 8 years industry experience is required, preferably in a biotechnology / biopharmaceutical environment
  • Experience in managing an Analytical Development Group
  • Expert in developing biophysical assays for characterization of monoclonal antibodies and other proteins
  • Experience with electrophoresis, HPLC and mass spectrometry
  • Proficient in analytical techniques including immunoassays and other plate based assays
  • Familiarity with GMP and GLP regulatory and industry guidance documents for drug development and product characterization
  • Experience in technology transfer
  • Experience with data management systems and statistical software
  • Demonstrated ability to work in a team and fast paced environment
  • Excellent written and verbal communication skills

Submit CV/Resume